Yes, Computers CAN be Funny!
Ridiculous Fish just released HexFiend 1.1 with a funny aside in the blog posting. If you're interested in how he does it, read his blog, and in particular read this article, and scroll down a little for a great laugh.
Apart from that, Stoneship (via garretmurray) found a hilarious movie for gaming freaks: EatPES's Game Over is the most hilarious stop-motion video I've seen in quite a while. You want to watch it, and if you know any gaming fans (or retro gaming fans), be sure to let them watch it with you. Especially if you're no gamer yourself.